National Workshop on Experimental Models of Post-Traumatic Epilepsy
March 10, 2023
This workshop is supported by a grant from the American Epilepsy Society
Attendees of this event learned the various facets of post-traumatic epilepsy (PTE) research to discover and advance therapeutic agents. This workshop for junior investigators imparted insightful and rigorous courses about animal models, lab protocols, biomarkers, and therapeutic interventions for traumatic brain injury (TBI) seizures and post-traumatic epileptogenesis.
Workshop Overview
TBI is a leading cause of epilepsy in military personnel and civilians. Spontaneous recurrent seizures (SRS) occur in the months or years following the injury, which is referred to as post-traumatic epilepsy (PTE). Currently, there is no effective treatment or cure for PTE, and therefore there is a great need to expand the research workforce in PTE research.
The main objective of this AES-sponsored workshop is to provide research training on PTE models with presentations and lab demonstrations to junior investigators. Panelists will present and discuss lab protocols and approaches to learning PTE models, with ample time for Q&A.
This workshop, chaired by Dr. Samba Reddy (Texas A&M) and expert researchers from leading institutes, is designed to offer deep insights into how TBI induction can lead to epileptogenesis and discuss PTE model protocols. It aims to help educate and expose researchers to exciting PTE research and provide opportunities for young investigators to interact with leaders in the field.
There was no registration fee. Sessions were held in person with a Zoom option available. Early-stage investigators, graduate students, postdocs, and research scientists benefited from training in the cutting-edge innovative research of PTE.
The Texas A&M team and speakers are excited to offer this workshop, which helped to educate researchers interested in pursuing research on TBI-induced epilepsy and interventions for PTE and its comorbidities.
Workshop Venue and Format
- Date: March 10, 2023
- Venue: Texas A&M University Bryan campus in facilities within the HPEP building (Lecture Hall #LL43AB), located at 8447 Riverside Parkway, Bryan, TX 77807.
- This workshop was offered both in person and via Zoom. Zoom links were sent to registered participants only.
- Lunch and refreshments were provided for in-person registered participants. A networking reception was hosted by the organizer.
Schedule of Events
8:10-8:30 AM |
Introduction & Opening Remarks (Chair) Samba Reddy, PhD/RPh, Professor & Director
Texas A&M Institute of Pharmacoogy and Neurotherapeutics
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8:30-9:00 AM |
Keynote Overview of Brain Response Following TBI & Modeling of PTE Ben Churn, PhD, Program Director, Channels, Synapses, and Circuits
NIH/NINDS, Rockville, MD
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9:00-9:40 AM |
Cortical Impact Injury Model of PTE in Mice (PTE Protocol #1) D. Samba Reddy, PhD, RPh, Professor
Texas A&M University School of Medicine, Bryan, TX
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9:40-10:20 AM |
Fluid Percussion Injury Model of PTE in Rats (PTE Protocol #2) Lee Shapiro, PhD, Associate Professor
Texas A&M School of Medicine, Bryan, TX
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10:20-11:00 AM |
Closed-Head Injury Model of TBI in Rats (PTE Protocol #3) Ashok Shetty, PhD, Professor
Texas A&M University College of Medicine, Bryan, TX
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11:00-11:20 AM |
Break |
11:20-Noon |
Diffuse Injury Model of PTE in Pigs (PTE Protocol #4) John A. Wolf, PhD, Assistant Professor of Neurosurgery
University of Pennsylvania, PA
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NOON-12:40 PM |
Canine Model of TBI & Injury (PTE Protocol #5) Nicholas Jeffery, DVM, Professor
Texas A&M College of Veterinary Medicine, College Station, TX
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12:40-1:30 PM |
Lunch & Networking |
1:30-2:10 PM |
Biomarkers of Experimental PTE Asla Pitkänen, PhD, Professor
University of Eastern Finland, Kuopio, Finland
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2:10-2:50 PM |
Age and Sex-specific Differences in PTE Models Aristea S. Galanopoulou, MD, PhD, Professor
Albert Einstein College of Medicine, Bronx, NY
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2:50-3:00 PM |
Break |
3:00-3:40 PM |
Experimental Approaches for PTE Interventions Detlev Boison, PhD, Professor
Rutgers University Medical School, New Brunswick, NJ
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3:40-4:20 PM |
Novel Disease-Modifying Therapeutics for PTE Chris Dulla, PhD, Associate Professor
Tufts University School of Medicine, Boston, MA
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4:20-5:00 PM |
Translational Impact of Sleep in PTE Models Rama Maganti, MD, Professor, Department of Neurology
University of Wisconsin-Madison, WI
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5:30-7:30 PM |
Networking Reception & Keynote Address Artificial Intelligence for Epilepsy Prognostics Roderic Pettigrew, PhD, MD (NAM, NAE, NAI), CEO EnHealth, Professor and Inaugural Dean
School of Engineering Medicine, Texas A&M University and Houston Methodist Hospital, Houston, TX
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