News & Publications

Reddy DS. Therapeutic and clinical foundations of cannabidiol therapy for difficult-to-treat seizures in children and adults with refractory epilepsies. Exp Neurol. 2022 Oct 4:114237. doi: 10.1016/j.expneurol.2022.114237.
https://pubmed.ncbi.nlm.nih.gov/36206806/

Reddy DS, Abeygunaratne HN. Experimental and Clinical Biomarkers for Progressive Evaluation of Neuropathology and Therapeutic Interventions for Acute and Chronic Neurological Disorders.
Int J Mol Sci. 2022 Oct 3;23(19):11734. doi: 10.3390/ijms231911734.
https://pubmed.ncbi.nlm.nih.gov/36233034/

Reddy DS, Mbilinyi RH, Ramakrishnan S. Efficacy of the FDA-approved cannabidiol on the development and persistence of temporal lobe epilepsy and complex focal onset seizures. Exp Neurol. 2022 Oct 7:114240. doi: 10.1016/j.expneurol.2022.114240.
https://pubmed.ncbi.nlm.nih.gov/36216124/

Talwar A, Estes E, Aparasu R, Reddy DS. Clinical efficacy and safety of cannabidiol for pediatric refractory epilepsy indications: A systematic review and meta-analysis. Exp Neurol. 2022 Oct 4:114238. doi: 10.1016/j.expneurol.2022.114238.
https://pubmed.ncbi.nlm.nih.gov/36206805/
https://www.sciencedirect.com/science/article/pii/S0014488622002631?dgcid=author

Reddy DS (2022). Book Chapter: Advances in Targeted Therapy of Organophosphate Neurotoxicity and Chemical Warfare Nerve Agents. In: Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects (Editors: Das, S., Thomas, S., Das, P.), Elsevier 1-11. 

Reddy DS, Golub VM, Ramakrishnan S, Abeygunaratne H, Dowell S, Wu X. A Comprehensive and Advanced Mouse Model of Post-Traumatic Epilepsy with Robust Spontaneous Recurrent Seizures. Curr Protoc. 2022 Jun;2(6):e447. doi: 10.1002/cpz1.447.
https://pubmed.ncbi.nlm.nih.gov/35671160/ 

Golub VM, Reddy DS. Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions. Pharmacol Rev. 2022 Apr;74(2):387-438. doi: 10.1124/pharmrev.121.000375.
https://pubmed.ncbi.nlm.nih.gov/35302046/ 

Afrin K, Dusi R, Reddy DS and Bukkapatnam STS (2022). Prognosis of epileptic seizure event onsets using random survival forests. IISE Transactions on Healthcare Systems Engineering 12(3): 221-231.  https://doi.org/10.1080/24725579.2022.2051645 

Golub VM, Reddy DS. Contusion brain damage in mice for modeling of post-traumatic epilepsy with contralateral hippocampus sclerosis: Comprehensive and longitudinal characterization of spontaneous seizures, neuropathology, and neuropsychiatric comorbidities. Exp Neurol. 2022 Feb;348:113946. doi: 10.1016/j.expneurol.2021.113946.
https://pubmed.ncbi.nlm.nih.gov/34896334/ 

Elmer S, Reddy DS. Therapeutic Basis of Generic Substitution of Antiseizure Medications. J Pharmacol Exp Ther. 2022 May;381(2):188-196. doi: 10.1124/jpet.121.000994
https://pubmed.ncbi.nlm.nih.gov/35241634/ 

Reddy DS, Zaayman M, Kuruba R and Wu X (2021). Comparative evaluation of experimental models of refractory status epilepticus following exposure of cholinergic agents pilocarpine, DFP, and soman. Neuropharmacology 191:108571. doi: 10.1016/j.neuropharm.2021.108571.
https://pubmed.ncbi.nlm.nih.gov/33878303/ 

Wu X, Shetty AK, Reddy DS. Long-term changes in neuroimaging markers, cognitive function and psychiatric symptoms in an experimental model of Gulf War Illness. Life Sci. 2021 Nov 15;285:119971. doi: 10.1016/j.lfs.2021.119971.
https://pubmed.ncbi.nlm.nih.gov/34560085/ 

Reddy DS, Thompson W, Calderara G. Molecular mechanisms of sex differences in epilepsy and seizure susceptibility in chemical, genetic and acquired epileptogenesis. Neurosci Lett. 2021 Apr 17;750:135753. doi: 10.1016/j.neulet.2021.135753.
https://pubmed.ncbi.nlm.nih.gov/33610673/

Reddy DS, Thompson W, Calderara G. Does Stress Trigger Seizures? Evidence from Experimental Models. Curr Top Behav Neurosci. 2022;55:41-64. doi: 10.1007/7854_2020_191.
https://pubmed.ncbi.nlm.nih.gov/33547597/ 

Golub V, Reddy DS. Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders. Adv Exp Med Biol. 2021;1264:93-110. doi: 10.1007/978-3-030-57369-0_7.
https://pubmed.ncbi.nlm.nih.gov/33332006/ 

Reddy DS. Brain structural and neuroendocrine basis of sex differences in epilepsy. Handb Clin Neurol. 2020;175:223-233. doi: 10.1016/B978-0-444-64123-6.00016-3.
https://pubmed.ncbi.nlm.nih.gov/33008527/ 

Christian CA, Reddy DS, Maguire J, Forcelli PA. Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies. Pharmacol Rev. 2020 Oct;72(4):767-800. doi: 10.1124/pr.119.017392.
https://pubmed.ncbi.nlm.nih.gov/32817274/ 

Reddy SD, Wu X, Kuruba R, Sridhar V, Reddy DS. Magnetic resonance imaging analysis of long-term neuropathology after exposure to the nerve agent soman: correlation with histopathology and neurological dysfunction. Ann N Y Acad Sci. 2020 Nov;1480(1):116-135. doi: 10.1111/nyas.14431.
https://pubmed.ncbi.nlm.nih.gov/32671850/ 

Reddy DS, Perumal D, Golub V, Habib A, Kuruba R, Wu X. Phenobarbital as alternate anticonvulsant for organophosphate-induced benzodiazepine-refractory status epilepticus and neuronal injury. Epilepsia Open. 2020 Apr 14;5(2):198-212. doi: 10.1002/epi4.12389.
https://pubmed.ncbi.nlm.nih.gov/32524045/ 

Chuang SH, Reddy DS. Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam. J Pharmacol Exp Ther. 2020 Mar;372(3):285-298. doi: 10.1124/jpet.119.261735
https://pubmed.ncbi.nlm.nih.gov/31843812/ 

Reddy DS. Mechanism-based novel antidotes for organophosphate neurotoxicity. Curr Opin Toxicol. 2019 Apr;14:35-45. doi: 10.1016/j.cotox.2019.08.001
https://pubmed.ncbi.nlm.nih.gov/32856007/ 

Reddy DS (2019). Neurosteroids: Biosynthesis, Mechanisms and Neurophysiological Function in the Brain. In: Hormonal Signaling in Biology and Medicine (Editor: Dr. Gerald Litwack), Academic press/Elsevier, pp-69-82. 

Reddy DS. An enigmatic role of tonic inhibition in gabapentin therapy. EBioMedicine. 2019 Apr;42:14-15. doi: 10.1016/j.ebiom.2019.03.047.
https://pubmed.ncbi.nlm.nih.gov/30910483/ 

Reddy DS, Carver CM, Clossen B, Wu X. Extrasynaptic γ-aminobutyric acid type A receptor-mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures.
Epilepsia. 2019 Apr;60(4):730-743. doi: 10.1111/epi.14693.
https://pubmed.ncbi.nlm.nih.gov/30895610/ 

Reddy SD, Younus I, Sridhar V, Reddy DS. Neuroimaging Biomarkers of Experimental Epileptogenesis and Refractory Epilepsy. Int J Mol Sci. 2019 Jan 8;20(1):220. doi: 10.3390/ijms20010220.
https://pubmed.ncbi.nlm.nih.gov/30626103/ 

Chuang SH, Reddy DS. Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus. Neuropharmacology. 2019 Apr;148:244-256. doi: 10.1016/j.neuropharm.2018.11.031.
https://pubmed.ncbi.nlm.nih.gov/30471294/ 

Reddy DS, Chuang SH, Hunn D, Crepeau AZ, Maganti R. Neuroendocrine aspects of improving sleep in epilepsy. Epilepsy Res. 2018 Nov;147:32-41. doi: 10.1016/j.eplepsyres.2018.08.013.
https://pubmed.ncbi.nlm.nih.gov/30212766/ 

Hamed R, Mohamed EM, Rahman Z, Khan MA (2021). 3D-printing of lopinavir printlets by selective laser sintering and quantification of crystalline fraction by XRPD-chemometric models. Int J Pharm. 592:120059 

Barakh Ali SF, Dharani S, Afrooz H, Khan MA, Mohamed EM, Kohli K, Rahman Z (2019). Application of salt engineering to reduce/mask bitter taste of clindamycin. Drug Dev Ind Pharm. 2019;45(12):1871-1878. 

Rahman Z, Charoo NA, Kuttolamadom MK, Asadi A, Khan MA (2019). Printing of personalized medication using binder jetting 3D printer. In: Precision medicine for investigators, practitioners and providers, Editor Faintuch J, Elsevier (In-press) 

Dharani S, Barakh Ali SF, Afrooz H, Bhattacharya R, Khan MA, Rahman Z (2019). Quality and In-Use Stability Comparison of Brand and Generics of Extended-Release Phenytoin Sodium Capsules. J Pharm Sci. 108(5):1808-1817. 

Rahman Z, Barakh Ali SF, Ozkan T, Charoo NA, Reddy IK, Khan MA (2018). Additive Manufacturing with 3D Printing: Progress from Bench to Bedside. AAPS J; 20(6):101 

Halawa AA, Rees KA, McCamy KM, Winzer-Serhan UH. 2020. Central and peripheral immune responses to low-dose lipopolysaccharide in a mouse model of the 15q13.3 microdeletion. Cytokine.;126: 154879. PMID: 31629107 

Rees KA, Halawa AA, Consuegra-Garcia D, Golub VM, Clossen BL, Tan AM, Montgomery KS, Samba Reddy D, Griffith WH, Winzer-Serhan UH. 2020. Molecular, physiological and behavioral characterization of the heterozygous Df[h15q13]/+ mouse model associated with the human 15q13.3 microdeletion syndrome. Brain Res.;1746:147024. PMID: 32712126

McCamy KM, Rees KA, Winzer-Serhan UH. Peripheral immune challenges elicit differential up-regulation of hippocampal cytokine and chemokine mRNA expression in a mouse model of the 15q13.3 microdeletion syndrome. Cytokine 2022 Nov;159:156005. doi: 10.1016/j.cyto.2022.156005. 

Broide RS, Winzer-Serhan UH, Chen Y, Leslie FM. (2019) Distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse. Front Neuroanat. 6;13:76. 

Powell J, Murray I, Johal J, and Elks M (2019) Effect of a small group, active learning, tutorial-based enrichment program (ICE) on student performance in medical physiology. Advances in Physiology Education 43(3):339-344 

Bordes SJ Jr, Gandhi J, Bauer B, Protas M, Solomon N, Bogdan L, Brummund D, Bass B, Clunes M, and Murray IVJ (2020) Using lectures to identify student misconceptions: A study on the paradoxical effects of hyperkalemia on vascular smooth muscle. Advances in Physiology Education. 2020 Mar 1;44(1):15-20. 

Okoreeh AK, Bake S, Sohrabji F. (2017) Astrocyte-specific insulin-like growth factor-1 gene transfer in aging female rats improves stroke outcomes. Glia. 65(7):1043-1058.PMID: 28317235. 

Perez-Gomez AA, Karmakar M, Carroll RJ, Kochan KJ, Lawley KS, Amstalden K, Young CR, Threadgill DW, Welsh CJ, Brinkmeyer-Langford C. Temporal Cytokine Profiles of Heterogeneous Mouse Models with TMEV-induced Neurological Disease. 2022. Cells 11(13):2044. PMCID: PMC9265636 

Perez-Gomez A, Karmakar M, Carroll RJ, Lawley KS, Amstalden K, Konganti K, Young CR, Threadgill DW, Welsh CJ, Brinkmeyer-Langford CL. Genetic and immunological contributors to virus-induced paralysis. 2021. Brain Behavior Immun-Health 18:100395. PMCID: PMC8645428. 

Lawley K, Rech R, Elenwa F, Han G, Perez Gomez AA, Amstalden K, Welsh CJ, Young CR, Threadgill DW, Brinkmeyer-Langford CL. Host genetic diversity drives variable central nervous system lesion distribution in chronic phase of Theiler's Murine Encephalomyelitis Virus (TMEV) infection. 2021. PLoS One. 16(8):e0256370. PMCID: PMC8378701 

Eldridge R, Osorio Hurtado D, Amstalden K, Edwards C, Young CR, Cai JJ, Konganti K, Hillhouse A, Threadgill DW, Welsh CJ, Brinkmeyer-Langford CL. Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies. 2020. Sci Rep. 10(1):7918. PMCID: PMC7220920 

Brinkmeyer-Langford CL, Amstalden K, Konganti K, Hillhouse A, Lawley KS, Perez-Gomez AA, Young CR, Welsh CJ, Threadgill DW. Resilience in long-term viral infection: genetic determinants and interactions. 2021. Int. J. Mol. Sci. 22(21):11379. PMCID: PMC858414. 

Brinkmeyer-Langford CL, Chu C, Balog C, Yu X, Cai JJ, Kornegay JN, Nabity M. Expression profiling of disease progression in canine model of Duchenne muscular dystrophy. 2018. PLoS One. 13(3):e0194485. PMID: 29554127 

Lane MA, Dulin JN, Fischer I. Transplanting neural progenitor cells to restore connectivity after spinal cord injury (2020). Nature Reviews Neuroscience 21:366-383. PMID: 32518349. 

Koffler J, Zhu W, Qu X, Platoshyn O, Dulin JN, Brock J, Graham L, Lu P, Sakamoto J, Marsala M, Chen S, Tuszynski MH (2019). Biomimetic 3D-printed scaffolds for spinal cord injury repair. Nature Medicine 25(2): 263-269. PMID: 30643285. 

Dulin JN, Adler AF, Kumamaru H, Lee-Kubli C, Poplawski G, Strobl H, Gibbs D, Kadoya K, Lu P, Fawcett JW, Tuszynski MH (2018). Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts. Nature Communications 9(1): 84. PMID: 29311559. 

Kadoya K, Lu P, Nguyen K, Lee-Kubli C, Kumamaru H, Yao L, Knackert J, Poplawski G, Dulin JN, Strobl H, Takashima Y, Biane J, Conner J, Zhang S-C, Tuszynski MH (2016). Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration. Nature Medicine 22(5): 479-87. PMID: 27019328. 

Sefiani A, Rusyn I, Geoffroy CG*. Novel Adult Cortical Neuron Processing and Screening method illustrates Sex- and Age-dependent effects of pharmaceutical compounds. bioRxiv, 2022.2003.2029.486299, doi:10.1101/2022.03.29.486299 (2022). 

Sutherland TC, Sefiani A, Horvat D, Huntington TE, Lei Y, West AP, Geoffroy CG*. Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons. Cells. 2021 Jun 29;10(7). doi: 10.3390/cells10071625.  

Sutherland TC, Geoffroy CG*. The Influence of Neuron-Extrinsic Factors and Aging on Injury Progression and Axonal Repair in the Central Nervous System. Front Cell Dev Biol. 2020;8:190 

Geoffroy CG*, Hilton BJ*, Tetzlaff W^#, Zheng B^#. Evidence for an age-dependent decline in axon regeneration in the adult mammalian central nervous system. Cell Rep. 2016 Apr 12;15(2):238-46. 

Chen M, Geoffroy CG, Meves JM, Narang A, Li Y, Nguyen MT, Khai VS, Kong X, Steinke C, Carolino KI, Elziere L, Goldberg MP, Jin Y, Zheng B. “Leucine Zipper-Bearing Kinase is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian Central Nervous System.” Cell Reports, 2018 March 27, 22, 1–11 

Grau, J. W., Huie, J. R., Garraway, S. M., Hook, M. A., Crown, E. D., Baumbauer, K. M., Lee, K. H., Hoy, K. C., & Ferguson, A. F.  (2012).  Impact of behavioral control on the processing of nociceptive stimulation.  Front Integrat Physiol, 3, 262. doi: 10.3389/fphys.2012.00262 PMC3429038. 

Grau, J. W., Huang, Y.-J., Turtle, J. D., Strain, M. M., Miranda, R. M., Garraway, S. M., & Hook, M. A. (2017). When pain hurts: Nociceptive stimulation induces a state of maladaptive plasticity and impairs recovery after spinal cord injury. J Neurotrauma. PMID: 27788626 

Grau, J.W. & Huang, Y.-Y. (2018) Metaplasticity within the spinal cord: Evidence brain-derived neurotrophic factor (BDNF), tumor necrosis factor (TNF), and alterations in GABA function (ionic plasticity) modulate pain and the capacity to learn. Neurobiol. Learn. Mem, 154, 121-135. PMID: 29635030 

Turtle, J. D., Brumley, M.K., Strain, M.M., Huang, Y.J., Miranda, R.C., & Grau, J.W. (2019). Engaging pain fibers after a spinal cord injury (SCI) fosters hemorrhage and expands the area of secondary injury. Exp Neurol, 311, 115-124. PMID: 30268767 

Grau, J. W., Baine, R. E., Bean, P. A., Davis, J. A., Fauss, G. N., Henwood, M. K., Hudson, K. E., Johnston, D. T., Tarbet, M. M., & Strain, M. M. (2020). Learning to promote recovery after spinal cord injury. Exp Neurol, 330. PMID: 32353465 

Hoy, K. C., Strain, M. M., Turtle, J. D., Lee, K. H., Huie, J. R., Hartman, J. J., Tarbet, M. M., Harlow, M. L, Magnuson, D. S. K., & Grau, J. W. (2020). Evidence that the central nervous system can induce a modification at the neuromuscular junction that contributes to the maintenance of a behavioral response. J Neurosci, 40, 9186-9209. PMID: 33097637 

Strain, M. M., Johnston, D. T., Baine, R.E., Reynolds, J.A., Huang, Y.-J., Henwood, M. K., Fauss, G. N., Davis, J. A., Miranda, R., West, C. R., & Grau, J. W. (2021). Hemorrhage and locomotor deficits induced by pain input after spinal cord injury are partially mediated by changes in hemodynamics. J Neurotrauma. 

O’Gorman M, Thakur S, Imrie G, Moran RL, Duboue E, Rohner N, McGaugh SE, and Keene AC, and Kowalko JE. Pleiotrpic function of the oca2 gene underlies the evolution of sleep loss and albinism in cavefish. (2021) Curr Biol. 31(16) 3694-3702. PMID 34293332. 

Jaggard JB, Lloyd E, Yuiska A, Patch A, Fily Y, Kowalko JE, Appelbaum L, Duboue ER, and Keene AC. Cavefish brain atlases reveal functional and anatomical convergence across independently evolved populations. (2020) Science Advances. 6, 38, eaba3126. PMID P32938683. 

Jaggard JB, Stahl BA, Lloyd E, Prober DA, Duboue ER and Keene AC. Hypocretin underlies the evolution of sleep loss in the Mexican cavefish. (2017) eLife, 10 (1101) 122903. PMID 29405117. 

Mack KL, Jaggard JB, Persons JL, Passow CN, Stahl BA, Ferrufino E, Tsuchiya D, Smith SE, Slaughter B, Kono JY, Kowalko JE, Rohner N, Keene AC, and McGaugh SE. Repeated evolution dysregulation of circadian clock dysregulation in cavefish populations. (2021) Plos Genetics, e1009642. PMID: 34252077. 

Palermo J, Chesi A, Zimerman A, Sonti Z, Sonti A, Lasconi C, Brown EP, Pippen JA, Wells AD, Doldur-Balli F, Mazzotti DR, Pack AI, Gehrman PR, Grant SFA, and Keene AC. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a novel regulator of sleep. Biorxiv (2021) 12.19.472248. 

Dharmalingam P, Talakatta G, Mitra J, Wang H, Derry PJ, Nilewski LG, McHugh EA, Fabian RH, Mendoza K, Vasquez V, Hegde PM, Kakadiaris E, Roy T, Boldogh I, Hegde VL, Mitra S, Tour JM*, Kent TA*, Hegde ML*. Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle. ACS Nano. 2020 Mar 24;14(3):2827-2846. doi: 10.1021/acsnano.9b05821. Epub 2020 Feb 21. 

Simard JM, Kent TA, Chen M, Tarasov KV, Gerzanich V. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurology 2007 Mar;6(3):258-68. 

Wu, G, McHugh EA, Berka, V, Chen W, Want A, Becham JL, Derry PJ, Roy T, Kent TA*, Tour JM*, Tsai A-L*. Oxidized activated charcoal nanoparticles as catalytic superoxide dismutase mimetics: Evidence for direct participation of an intrinsic radical. ACS Applied Nano Materials 2020. 3 (7), 6962-6971. 

Derry PJ, Nilewski LG, Sikkema WKA, Mendoza K, Jalilov A, Berka V, McHugh EA, Tsai AL, Tour JM, Kent TA. Catalytic oxidation and reduction reactions of hydrophilic carbon clusters with NADH and cytochrome C: features of an electron transport nanozyme. Nanoscale 2019 11(22): 10791-10807. PMID: 31134256 

Griffin DM, Bitner BR, Criss Ii Z, Marcano D, Berlin JM, Kent TA, Tour JM, Samson SL, Pautler RG. Use of a bioengineered antioxidant in mouse models of metabolic syndrome. Expert Opin Investig Drugs. 2020 Feb;29(2):209-219. doi: 10.1080/13543784.2020.1716216. Epub 2020 Jan 20. PMID: 3193715 

Tsivgoulis G, Katsanos AH, Eggers J, Larrue V, Thomassen L, Grotta JC, Seitidis G, Schellinger PD, Mavridis D, Demchuk A, Novotny V, Molina CA, Veroniki AA, Köhrmann M, Soinne L, Khanevski AN, Barreto AD, Saqqur M, Psaltopoulou T, Muir KW, Fiebach JB, Rothlisberger T, Kent TA, Mandava P, Alexandrov AW, Alexandrov AV. Sonothrombolysis in Patients With Acute Ischemic Stroke With Large Vessel Occlusion: An Individual Patient Data Meta-Analysis. Stroke. 2021 Dec;52(12):3786-3795. doi: 10.1161/STROKEAHA.120.030960. Epub 2021 Aug 25. PMID: 34428930. 

Van Sandt RL, Welsh CJ, Jeffery ND, Young CR, McCreedy DA, Wright GA, Boudreau E, Levine GJ, Levine JM. Circulating neutrophil activation in dogs with naturally occurring spinal cord injury secondary to intervertebral disk herniation. American Journal of Veterinary Research. 83(4):324-330. 2022. 

McCreedy DA, Abram CL, Hu Y, Min SW, Platt ME, Kirchhoff MA, Reid SK, Jalufka FL, Lowell CA. Spleen tyrosine kinase facilitates neutrophil activation and worsens long-term neurologic deficits after spinal cord injury. Journal of Neuroinflammation. 18(1): 302, 2021. PMC8705173 

McCreedy DA*#, Lee S*, Sontag CJ, Weinstein P, Olivas A, Martinez AF, Fandel T, Trivedi A, Rosen SD, Noble-Haeusslein LJ. Early Targeting of L-selectin on Leukocytes Promotes Long-term Recovery after Spinal Cord Injury, Implicating Novel Mechanisms of Pathogenesis. eNeuro. 5(4): 0101-18, 2018. PMC6140118.

Jalufka FL, Min SW, Platt ME, Pritchard AL, Margo TE, Vernino AO, Kirchhoff MA, Massopust RT, McCreedy DM. Hydrophobic and Hydrogel-based Methods for Passive Tissue Clearing. Methods in Molecular Biology. 2440: 197-209, 2022. 

McCreedy DM, Jalufka FL, Platt ME, Min SW, Kirchhoff MA, Pritchard AL, Reid SK, Manlapaz R, Mihaly E, Butts JC, Iyer NR, Sakiyama-Elbert SE, Crone SA, McDevitt TC. Passive clearing and 3D lightsheet imaging of the intact and injured spinal cord in mice. Frontiers in Cellular Neuroscience. 15: 684792, 2021. PMC8366232. 

Massopust RT, Lee Y, Pritchard AL, Nguyen VM, McCreedy DA, Thompson WJ. Lifetime Analysis of Mdx Skeletal Muscle Reveals a Progressive Pathology that Leads to Myofiber Loss. Scientific Reports. 10(1): 17248, 2020. PMC7560899. 

Newell-Rogers M.K.; Rogers^, S.K.; Tobin, R.P.; Mukherjee^, S.; and Shapiro, L.A. 2020.  Antagonism of macrophage migration inhibitory factor (MIF) after traumatic brain injury ameliorates peripheral lymphocyte activation and expansion, and hippocampal astrocytosis. Int J Mol Sci. 2020 Oct 9;21(20):7448. doi: 10.3390/ijms21207448. PMID: 33050322. 

Van Beusecum, JP; Zhang S; Beltran, E.; Cook, AK; Tobin, RP; Newell-Rogers, MK; and Inscho, EW.  2019. Am. J. Physiol Renal Physiol.  Antagonism of major histocompatibility complex class II invariant chain peptide during chronic lipopolysaccharide treatment rescues autoregulatory behavior.  DOI:  10.1152/ajprenal.00164.2019. PMID: 31432707 

Van Beusecum, JP; Zhang S; Beltran, E.; Cook, AK; Tobin, RP; Newell-Rogers, MK; and Inscho, EW.  2019. Am. J. Physiol Renal Physiol.  Antagonism of major histocompatibility complex class II invariant chain peptide during chronic lipopolysaccharide treatment rescues autoregulatory behavior.  DOI:  10.1152/ajprenal.00164.2019. PMID: 31432707 

Seaberg BL, Purao S, Rimer M. (2022). Validation of terminal Schwann cell gene marker expression by fluorescent in situ hybridization using RNAscope. Neurosci. Lett. 771, 136468; doi: 10.1016/j.neulet.2022.136468. PMCID: PMC8821205. 

Rimer M. (2020). Extracellular-signal regulated kinases 1 and 2 regulate neuromuscular junction and myofiber phenotypes in mammalian skeletal muscle. Neurosci. Lett. 715, 134671 ; doi: 10.1016/j.neulet.2019.134671. PMCID: PMC6956858. 

Rimer M, Seaberg BL, Yen P-F, Lam S, Hastings RL, Lee YI, Thompson WJ, Feng Z, Metzger F, Paushkin S, and Ko C-P. (2019). Nerve sprouting capacity in a pharmacologically induced mouse model of spinal muscular atrophy. Sci. Rep. 9, 7799. PMID: 31127156. PMCID: PMC6534600. 

Tobin RP, Mukherjee S, Kain JM, Rogers SK, Henderson SK, Motal H, Newell Rogers MK, and Shapiro LA. Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration. Acta Neuropathol Commun. 2014 Oct 20;2(1):143. PMID: 25329434.

Newell Rogers MK.; Rogers^, SK.; Tobin, RP.; Mukherjee^, S.; and Shapiro, LA. 2020.  Antagonism of macrophage migration inhibitory factory (MIF) after traumatic brain injury ameliorates peripheral lymphocyte activation and expansion, and hippocampal astrocytosis. Int J Mol Sci. 2020 Oct 9;21(20):7448. doi: 10.3390/ijms21207448. PMID: 33050322.

Brakel K, Aceves M,  Garza A, Yoo C, Escobedo Jr. G, Panchani N,   Shapiro LA, Hook M. Inflammation increases the development of depression behaviors in male rats after spinal cord injury. Brain Behav. Immune. - Health. 2021, July: 14, ISSN 2666-3546. 

Nizamutdinov D, DeMorrow S, McMillin M, Kain J, Mukherjee S, Zeitouni S, Frampton G, Bricker PC, Hurst J, Shapiro LA. (2017) Hepatic alterations are accompanied by changes to bile acid transporter-expressing neurons in the hypothalamus after traumatic brain injury. Scientific Reports: 7:40112. PMID 28106051 

Kodali M, Castro OW, Kim DK, Thomas A, Shuai B, Attaluri S, Upadhya R, Gitai D, Madhu LN, Prockop DJ, Shetty AK. (2020). Intranasally administered human MSC-derived EVs pervasively incorporate into neurons and microglia in both intact and SE-injured forebrain. Int J Mol Sci. 21:181. 

Upadhya R, Madhu L, Attaluri S, Gitai D, Pinson M, Kodali M, Kumar S, Shuai B, Weintraub ST, Shetty AK (2020). Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and antiinflammatory and neurogenic properties. J Extracellular Vesicles, 9: 1809064. 

Kodali M, Attaluri S, Madhu LN, Shuai B, Upadhya R, Gonzalez JJ, Rao X Shetty AK (2021). Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus. Aging Cell, 20(2): e13277.

Madhu LN, Attaluri S, Kodali M, Shuai B, Upadhya R, Gitai D, Shetty AK. (2019). Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood. Brain, Behavior and Immunity, 81:430-443. 

Shetty AK, Attaluri S, Kodali M, Shuai B, Shetty GA, Upadhya D, Hattiangady B, Madhu LN, Upadhya R, Bates A, Rao X. (2020). Monosodium luminol reinstates redox homeostasis, improves cognition, mood, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness. Redox Biology, 28:101389. 

Lee S*, Singh I*, Lee S, Tisdale S, Abdel-Wahab O, Leslie C, Mayr C, “Widespread intronic polyadenylation inactivates tumor suppressor genes in leukemia”, Nature 561, 127–131 (2018) PMID: 30150773 (*Co-first authors)

Singh I, Lee S, Sperling A, Samur MK, Tai Y, Fulciniti M, Munshi N, Mayr C, Leslie C “Widespread intronic polyadenylation diversifies immune cell transcriptomes”, Nature Communications 9: 1716 (2018) PMID: 29712909

Carrow JK, Cross L, Reese R. W, Jaiswal M, Gregory C, Kaunas R, Singh I*, Gaharwar AK. Widespread Changes in Transcriptome Profile of Human Mesenchymal Stem Cells Induced by Two-Dimensional (2D) Nanosilicates. Proceedings of the National Academy of Sciences 2018 Apr 24;115(17): E3905-E3913. PMCID: PMC5924886

Brokesh A, Cross L, Kersey A, Murali A, Richter C, Gregory C, Singh I*, Gaharwar AK*, “Dissociation of Nanosilicates Induces Downstream Endochondral Differentiation Gene Expression Program” Science Advances 8, 17, abl9404 (2022). PMID: 35476448 

Carrow J., Singh KA, Jaiswal MK, Ramirez A, Lokhande A, Yeh A, Sarkar TA, Singh I^#, Gaharwar AK^#.  Photothermal Modulation of Human Stem Cells Using Light-responsive 2D Nanomaterials. Proceedings of the National Academy of Sciences 117 (24), 13329-13338 (2020). PMID: 32461372 

Gaharwar AK, Singh I, Khademhosseini A, Engineered Biomaterials for In situ Tissue Regeneration. Nature Review Materials 5, 686–705 (2020). 

Chimene D, Miller L, Cross L, Jaiswal MK, Singh I, Gaharwar AK. Nanoengineered Osteoinductive Bioink for 3D Bioprinting Bone Tissue. ACS Applied Materials & Interfaces 2020, 12 (14), 15976-15988 

Sohrabji, F., Park, M. J., & Mahnke, A. H. (2017). Sex differences in stroke therapies. J Neurosci Res, 95(1-2), 681-691. PMC5125551 

Galea LAM, Choleris E, Albert AYK, McCarthy MM, Sohrabji F. (2020) The promises and pitfalls of sex difference research. Front Neuroendocrinol. PMC7050281. 

Park, MJ, Pilla, R, Panta A, Pandey S, Sarawichitr B, Suchodolski J, Sohrabji, F. (2020) Reproductive Senescence and Ischemic Stroke Remodel the Gut Microbiome and Modulate the Effects of Estrogen Treatment in Female Rats. Transl Stroke Res, 11: 812-830. PMID31845185 

Panta A, Pandey S, Duncan IN, Duhamel S, Sohrabji F. (2019) Mir363-3p attenuates post-stroke depressive-like behaviors in middle-aged female rats.  Behav Immun.78:31-40. PMID 30639697. 

Panta A, M.K., Nicolas M, Mani KK, Sampath D, Sohrabji F (2020) Mir363-3p treatment attenuates delayed cognitive deficits precipitated by ischemic stroke in middle-aged female rats Frontiers in Aging Neuroscience DOI: 10.3389/fnagi.2020.586362. 

El-Hakim Y, Mani KK, Eldouh A, Pandey S, Grimaldo MT, Dabney A, Sohrabji, F. Sex differences in stroke outcome correspond to rapid and severe changes in gut permeability in adult Sprague-Dawley rats. Biol Sex Differ. 2021;12(1):14. Epub 2021/01/17. PMID: 33451354 

Zarate SM*, Pandey G*, Chilukuri S, Garcia JA, Cude B, Storey S, Salem NA, Bancroft EA, Hook M, Srinivasan R (2021). Cytisine is neuroprotective in female but not male 6‐hydroxydopamine lesioned parkinsonian mice and acts in combination with 17‐β‐estradiol to inhibit apoptotic endoplasmic reticulum stress in dopaminergic neurons. Journal of Neurochemistry. 157(3):710-726. PMID: 33354763 

Huntington TE, Srinivasan R (2021) Astrocytic mitochondria in adult mouse brain slices show spontaneous calcium influx events with unique properties. Cell Calcium. doi: 10.1016/j.ceca.2021.102383. PMID: 33676316 

Bancroft EA, Srinivasan R (2022) Emerging roles for aberrant astrocytic calcium signals in Parkinson’s disease. Frontiers in Physiology. doi: 10.3389/fphys.2021.812212. PMID: 35087422

Bancroft EA, De La Mora M, Pandey G, Zarate SM, Srinivasan R (2022) Extracellular S100B inhibits A-type voltage-gated potassium currents and increases L-type voltage-gated calcium channel activity in dopaminergic neurons. GLIA. doi: 10.1002/glia.24254 

Zhang H, Lu Y, Qin C. Intracranial calcification phenotypes in Fam20C-deficient mice recapitulate human Raine syndrome. J Dent Res. 2018, 97 (Spec Iss B): 0489. 

Zhang H, Lu Y, Qin C. FAM20C is essential for maintaining brain homeostasis. FASEB J. 2019, 33 (1_supplement), 335.2-335.2 

Zhang H, Li L, Kesterke MJ, Lu Y, and Qin C. High-phosphate Diet improved the skeletal development of Fam20c-deficient mice. Cells Tissues Organs. 2019; 208(1-2):25-36. Epub 2020 Feb 26. (PMCID: PMC7192785). 

Zhang H, Xu Q, Lu Y, Qin C. Effect of high phosphate diet on the formation of dentin in Fam20c-deficient mice. Eur J Oral Sci. 2021 Jun;129(3):e12795. doi: 10.1111/eos.12795. Epub 2021 Apr 27. PubMed PMID: 33905141. 

Liang T, Zhang H, Xu Q, Wang S, Qin C, Lu Y. Mutant dentin sialophosphoprotein causes dentinogenesis imperfecta. J Dent Res. 2019 Jul; 98 (8): 912-919. (PMCID: PMC6616118). 

Earnest DJ, Burns S, Pandey S, Mani KK, Sohrabji F. Sex differences in the diathetic effects of shift work schedules on circulating cytokine levels and pathological outcomes of ischemic stroke during middle age. Neurobiol Sleep Circadian Rhythms. 2022 Jun 23;13:100079. doi: 10.1016/j.nbscr.2022.100079.

Earnest DJ, Neuendorff N, Coffman J, Selvamani A, Sohrabji F. Sex Differences in the Impact of Shift Work Schedules on Pathological Outcomes in an Animal Model of Ischemic Stroke. Endocrinology. 2016 Jul;157(7):2836-43. doi: 10.1210/en.2016-1130. 

Wei Wang, Xueyi Xie, Xiaowen Zhuang, Yufei Huang, Tao Tan, Himanshu Gangal, Zhenbo Huang, William Purvines, Xuehua Wang, Alexander Stefanov, Ruifeng Chen, Emily Yu, Michelle Hook, Yun Huang, Emmanuel Darcq, and Jun Wang. Striatal Mu-Opioid Receptor Activation Triggers Direct-Pathway GABAergic Plasticity to Induce Negative Affect. BioRxiv (2022).

Tengfei Ma, Zhenbo Huang, Xueyi Xie, Xiaowen Zhuang, Matthew Childs, Himanshu Gangal, Xuehua Wang, Laura N Smith, Rachel J Smith, Yubin Zhou, and Jun Wang. Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility. The Journal of Clinical Investigation, 2021, doi:10.1172/JCI154969 (2021).

Yifeng Cheng, Xueyi Xie, Jiayi Lu, Himanshu Gangal, Wei Wang, Sebastian Melo, Xuehua Wang, Jared Jerger, Kayla Woodson, Eric Garr, Yufei Huang, Patricia Janak, Jun Wang. Optogenetic induction of orbitostriatal long-term potentiation in the dorsomedial striatum elicits a persistent reduction of alcohol-seeking behavior in rats. Neuropharmacology 191:108560 (2021).

Jiayi Lu, Yifeng Cheng, Xueyi Xie, Kayla Woodson, Jordan Bonifacio, Emily Disney, Britton Barbee, Xuehua Wang, Marian Zaidi, Jun Wang. Whole-brain mapping of direct inputs to dopamine D1 and D2 receptor-expressing medium spiny neurons in the posterior dorsomedial striatum. eNeuro, 8:0348-0320.2020.

Huebschman JL, Davis MC, Tovar Pensa C, Guo Y, Smith LN. The fragile X mental retardation protein promotes adjustments in cocaine self-administration that preserve reinforcement level. Eur J Neurosci. 2021 Aug;54(3):4920-4933. doi: 10.1111/ejn.15356.

Huebschman JL, Corona KS, Guo Y, Smith LN. The Fragile X Mental Retardation Protein Regulates Striatal Medium Spiny Neuron Synapse Density and Dendritic Spine Morphology. Front Mol Neurosci. 2020 Sep 10;13:161. doi: 10.3389/fnmol.2020.00161

Chung DD, Pinson MR, Bhenderu LS, Lai MS, Patel RA, Miranda RC. Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood. Int J Mol Sci. 2021 Aug 16;22(16):8785. doi: 10.3390/ijms22168785.

Mahnke AH, Adams AM, Wang AZ, Miranda RC. Toxicant and teratogenic effects of prenatal alcohol. Curr Opin Toxicol. 2019 Apr;14:29-34. doi: 10.1016/j.cotox.2019.08.002.

Mahnke AH, Salem NA, Tseng AM, Chung DD, Miranda RC. Nonprotein-coding RNAs in Fetal Alcohol Spectrum Disorders. Prog Mol Biol Transl Sci. 2018;157:299-342. doi: 10.1016/bs.pmbts.2017.11.024

Bake S, Hurst DA, Miranda RC, Sohrabji F. Prenatal alcohol exposure exacerbates acute sensorimotor deficits and impedes long-term behavioral recovery resulting from adult-onset cerebrovascular ischemic stroke. Alcohol Clin Exp Res. 2022 Oct 6. doi: 10.1111/acer.14952.

Pinson MR, Tseng AM, Adams A, Lehman TE, Chung K, Gutierrez J, Larin KV, Chambers C, Miranda RC; Collaborative Initiative on Fetal Alcohol Spectrum Disorders. Prenatal alcohol exposure contributes to negative pregnancy outcomes by altering fetal vascular dynamics and the placental transcriptome. Alcohol Clin Exp Res. 2022 Jun;46(6):1036-1049. doi: 10.1111/acer.14846.

Aceves M, Terminel MN, Okoreeh A, Aceves AR, Gong YM, Polanco A, Sohrabji F, Hook MA.Morphine increases macrophages at the lesion site following spinal cord injury: Protective effects of minocycline. Brain Behav Immun. 2019 Jul;79:125-138. doi: 10.1016/j.bbi.2019.01.023

Terminel MN, Bassil C, Rau J, Trevino A, Ruiz C, Alaniz R, Hook MA. Morphine-induced changes in the function of microglia and macrophages after acute spinal cord injury. BMC Neurosci. 2022 Oct 10;23(1):58. doi: 10.1186/s12868-022-00739-3.

Golub V and Reddy DS (2019). Neurodegeneration of Inhibitory Interneurons in the Hippocampus Correlates with Onset and Progression of an Experimental Post-traumatic Epilepsy. American Epilepsy Society Annual Meeting (Dec 9, 2019), Baltimore, MD.

Wu X, Park M-J, Kuruba R, Sohrabji F and Reddy DS (2019). The long-term epileptogenic impact of stroke in mature adult and reproductive senescent female rats. American Epilepsy Society Annual Meeting (Dec 7, 2019), Baltimore, MD.

Reddy DS (2019). Recent Advances and Regulatory Challenges in Developing New Drugs for Brain Disorders. Association of Biotechnology and Pharmacy Meeting and International Conference (Dec 20, 2019), Guntur, India.

Reddy DS (2020). Current prospects for developing vaccines and antivirals for COVID-19. Two-day International Webinar on Challenges and Strategies in Combating COVID-19 -- Virtual Conference (August 13, 2020), Tirupati, India. 

Reddy DS (2020). Pharmaceutical race for developing vaccines and antivirals for COVID-19. International Webinar on Role of Pharmacology in Drug Discovery -- Virtual Conference (August 17, 2020), Chennai, India.

Reddy (2020). Development and approval of first neurosteroid for clinical therapy. International FDP/ SDP on Drug Discovery and Development Symposium -- Virtual Conference (June 25, 2020). Bhimavaram, India. 

Wu X, Shetty A and Reddy DS (2020). Neurosteroid Mitigation of Neurological Dysfunction in an Experimental Model of Gulf War Illness. 2020 Virtual Gulf War Illness (GWI)-State of the Science Conference -- Virtual Conference (August 18-19, 2020), Washington, DC.

Golub V and Reddy DS (2020). Hyperactivation of Epigenetic HDAC Pathway in an Experimental Model of Acquired Epilepsy. American Epilepsy Society Annual Meeting- Virtual Conference (December 3-6, 2020), Seattle, WA.

Wu X, Shetty A and Reddy DS (2020). Seizure-Independent Long-Term Cognitive Dysfunction and Depression in an Experimental Model of GWI Chemical Neurotoxicity. American Epilepsy Society Annual Meeting- Virtual Conference (December 3-6, 2020), Seattle, WA. 

Wu X, Shetty AK and Reddy DS (2021). Long-term Changes in Neuroimaging Markers, Cognitive Function and Psychiatric Symptoms in an Experimental Model of Gulf War Illness. Society for Neuroscience Annual Meeting (October 16, 2021), New Orleans, LA.

Wu X, Zaayman M, Kuruba R and Reddy DS (2021). Comparative profile of refractory status epilepticus models following exposure of three distinct cholinergic agents. American Epilepsy Society Annual Meeting- (December 3-6, 2021), Chicago, IL.

Golub V and Reddy DS (2021). Age-related Differences in the Development of Post-traumatic Epilepsy and its Comorbidities. American Epilepsy Society Annual Meeting- (December 3-6, 2021), Chicago, IL.

Wu X and Reddy DS (2021). Comparative profile of refractory SE models following exposure of cholinergic agents. Experimental Biology Meeting (April 27-30, 2021), Washington, DC (Virtual). 

Wu X, Shetty A and Reddy DS (2021). Long-term Changes in Neuroimaging Markers, Cognitive Function and Psychiatric Symptoms in an Experimental Model of Gulf War Illness. Society for Neuroscience Annual Meeting (November 8-11, 2021), Washington, DC (Virtual).

Reddy DS and Wu X (2021). Long-term Changes in Neuroimaging Markers, Cognitive Function and Psychiatric Symptoms in an Experimental Model of Gulf War Illness. Military Health System Research Symposium (August 20, 2021), Orlando, FL. Abstr#MHSRS-21-02334. 

Reddy DS (2021). Cell-Specific and Phosphorylation-Dependent Actions of Brexanolone (Allopregnanolone) Analogs in Epilepsy and Brain Disorders. SATELLITE SYMPOSIUM "ALLOPREGNANOLONE AND ITS SYNTHETIC ANALOGUES" 11TH INTERNATIONAL MEETING ON: "STEROIDS AND NERVOUS SYSTEM" (Feb 21, 2021), Torino, Italy.

Reddy DS (2021). Neurosteroid Replacement Therapy for Epilepsy and Brain. International Brain Research Organization Symposium, 5th IBRO/APRC Chandigarh Neuroscience School (Aug 23, 2021), Chandigarh, India.

Reddy DS (2021). Psychotropic medications in seizure disorders. Invisible Scars: Adverse Childhood Events and Physician Wellness (CME Lecture). Annual Virtual Live CME Webinar of Texas Society of Psychiatric Physicians (Nov 6, 2021), August, TX. 

Ramakrishnan S, Singh T, Wu X, and Reddy DS (2022). Long-term Seizures, Neuropathology and Behavioral Response of Adult Rats after OP Status Epilepticus: Effect of Novel Neuroprotectants. American Epilepsy Society Annual Meeting (Dec 3, 2022), Nashville, TN.

Elmer S and Reddy DS (2022). Generic substitution of antiseizure medications: Is it time for narrow therapeutic index classification? American Academy of Neurology Annual Meeting (April 2-7, 2022), Seattle, WA. 

Singh T, Ramakrishnan S, Wu X, and Reddy DS (2022). Seizure Susceptibility and Developmental Alterations of Pediatric Rats after OP Status Epilepticus: Mitigation by Novel Anticonvulsants. American Epilepsy Society Annual Meeting (Dec 3, 2022), Nashville, TN.

Wu X, Singh T, Ramakrishnan S, and Reddy DS (2022). Sex Differences in Electrographic Activity and Neuronal Injury Patterns in the DFP Model of Status Epilepticus. American Epilepsy Society Annual Meeting (Dec 3, 2022), Nashville, TN. 

Wu X, Singh T, Neff M and Reddy DS (2022). Neuropathological and Behavioral Profile of a Chronic Experimental GWI Model Reminiscent of Neuropsychiatric Signs in Veterans. Society for Neuroscience Annual Meeting (Nov 12-16, 2022), San Diego, CA.

Skrobarczyk L, Ramakrishnan S, and Reddy DS (2022). Progression of Epileptogenesis and Comorbid Behavior Patterns after Traumatic Brain Injury in Aged Mice. American Epilepsy Society Annual Meeting (Dec 2, 2022), Nashville, TN. 

Neff M, Singh T, Wu X and Reddy DS (2022). Long-term Developmental Neuropsychiatric Comorbidities of Pediatric Exposure to DFP Status Epilepticus. American Epilepsy Society Annual Meeting (Dec 2, 2022), Nashville, TN.

Reddy DS (2022). Pharmacological approaches to modulate seizure susceptibility and presentation in laboratory animals: best practices. Basic Science Skills Workshop: Addressing Sex as a Biological Variable in Epilepsy and Beyond. American Epilepsy Society Annual Meeting (Dec 2, 2022), Nashville, TN.